With the exception of the 50 cent 'shinplasters' - which had printed signatures - every single Confederate Treasury Note was hand-signed, by representatives of both the Register and the Treasurer.  

Almost 400 people were employed by the Confederate Treasury Note Bureau to sign the huge quantities of notes that were issued during the period 1861-1865.

At the beginning of the War only men were able to hold this position of responsibility at the Treasury. However, as the War progressed, most male clerks were enlisted in the military, and the note signing responsibilities transitioned to women. Early notes were issued from Montgomery, Alabama, but soon Richmond, Virginia became the home of the Treasury, until April 1864 when operations were forced to move to Columbia, South Carolina.

Mike McNeil and Charles Derby have recently undertaken extensive research on the Signers and their lives, and this has been incorporated into a comprehensive book on the subject.